2018年系统和网络药理学原理、方法及应用研讨班(第6期)即将开课!
CancerHSP
Parameters in CancerHSP
  1.  IC50: half minimal (50%) inhibitory concentration

  2. The IC50 of a drug can be determined by constructing a dose-response curve and examining the effect of different concentrations of the drug in inhibiting a specific biological or biochemical function.

  3.  ED50: median effective dose

  4. The "median effective dose" is the dose that produces a quantal effect (all or nothing) in 50% of the population that takes it (median referring to the 50% population base). The ED50 is commonly used as a measure of the reasonable expectancy of a drug effect, but does not necessarily represent the dose that a clinician might use.

  5.  GI50: Growth inhibition of 50%

  6. GI50 is calculated from [(Ti-Tz)/(C-Tz)] x 100 = 50, (where Tz is time zero, C is control growth, and Ti is test growth in the presence of drug at the five concentration levels) which is the drug concentration resulting in a 50% reduction in the net protein increase (as measured by SRB staining) in control cells during the drug incubation.

  7.  EC50: half maximal effective concentration

  8. EC50 refers to the concentration of a drug, antibody or toxicant which induces a response halfway between the baseline and maximum after a specified exposure time.

  9.  LC50: lethal concentration

  10. LC50 (or LD50, LCt50) of a toxin, radiation, or pathogen is the dose required to kill half the members of a tested population after a specified test duration.

  11.  OB: oral bioavailability

  12. OB represents the percentage of an orally administered dose of unchanged drug that reaches the systemic circulation, which reveals the convergence of the ADME process.

  13.  BBB: blood-brain barrier

  14. BBB is anatomically characterized by the presence of intercellular tight junctions between continuous non-fenestrated endothelial cells.

  15.  Caco-2: 

  16. Caco-2 represents the ingredients' transport rates (nm/s) in Caco-2 monolayers.

  17.  MW: molecular weight

  18. MW refers to the mass of a molecule.

  19.  AlogP:

  20. Caco-2 represents the ingredients' transport rates (nm/s) in Caco-2 monolayers.

  21.  Hdon: 

  22. The number of possible hydrogen-bond donors.

  23.  Hacc: 

  24. The number of possible hydrogen-bond acceptors.

  25.  RBN:

  26. RBN is the number of bonds which allow free rotation around themselves.

  27.  TPSA:

  28. TPSA is a physico chemical property describing the polarity of molecules.



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